2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Cannabinoid Receptor

Cannabinoid Receptor

Cannabinoid Receptor

Cannabinoid Receptor

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Cannabinoid receptors are currently classified into three groups: central (CB1), peripheral (CB2) and GPR55, all of which are G-protein-coupled. CB1 receptors are primarily located at central and peripheral nerve terminals. CB2 receptors are predominantly expressed in non-neuronal tissues, particularly immune cells, where they modulate cytokine release and cell migration. Recent reports have suggested that CB2 receptors may also be expressed in the CNS. GPR55 receptors are non-CB1/CB2 receptors that exhibit affinity for endogenous, plant and synthetic cannabinoids. Endogenous ligands for cannabinoid receptors have been discovered, including anandamide and 2-arachidonylglycerol.

Cannabinoid Receptor Isoform Specific Products:

Cannabinoid Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-171024
    Cannabinol ethyl
    Cannabinol ethyl (CBN-C2) is structurally similar to known phytocannabinoids.
    Cannabinol ethyl
  • HY-168790
    8(S)-Hydroxy-9(S)-hexahydrocannabinol
    8(S)-Hydroxy-9(S)-hexahydrocannabinol is structurally similar to known phytocannabinoids.
    8(S)-Hydroxy-9(S)-hexahydrocannabinol
  • HY-170695
    exo-THCP
    exo-THCP (exo-Tetrahydrocannabiphorol) is structurally similar to known phytocannabinoids.
    exo-THCP
  • HY-W008364R
    Olivetol (Standard)
    		Inhibitor
    Olivetol (Standard) is the analytical standard of Olivetol. This product is intended for research and analytical applications. Olivetol is a naturally phenol found in lichens and produced by certain insects, acting as a competitive inhibitor of the cannabinoid receptors CB1 and CB2. Olivetol also inhibits CYP2C19 and CYP2D6 activity, with IC50s of 15.3 μM, 7.21 μM and Kis of 2.71 μM, 2.87 μM, respectively.
    Olivetol (Standard)
  • HY-170041
    (±)-6',7'-Dihydroxy cannabichromene
    (±)-6',7'-Dihydroxy cannabichromene is a phytocannabinoid metabolite.
    (±)-6',7'-Dihydroxy cannabichromene
  • HY-W195039
    5-Heptylresorcinol
    5-Heptylresorcinol is a precursor in the synthesis of cannabidiphorol.
    5-Heptylresorcinol
  • HY-150348
    Cannabidivarin diacetate
    Cannabidivarin diacetateis structurally similar to known phytocannabinoids.
    Cannabidivarin diacetate
  • HY-170739
    Δ9-THCBA-A
    Δ9-THCBA-A (Δ9-Tetrahydrocannabinolic acid-C4) is structurally similar to known phytocannabinoids.
    Δ9-THCBA-A
  • HY-170042
    5'-Hydroxy-9(S)-hexahydrocannabinol
    5'-Hydroxy-9(S)-hexahydrocannabinol is structurally similar to known phytocannabinoids.
    5'-Hydroxy-9(S)-hexahydrocannabinol
  • HY-121830
    5Z,8Z,11Z,14Z-Eicosatetraenoic acid, 3-thienylmethyl ester
    5Z,8Z,11Z,14Z-Eicosatetraenoic acid, 3-thienylmethyl ester is a Anandamide (HY-10863) analog. Anandamide is an endocannabinoid.
    5Z,8Z,11Z,14Z-Eicosatetraenoic acid, 3-thienylmethyl ester
  • HY-172082
    MEP-FUBICA
    MEP-FUBICA is structurally categorized as a synthetic cannabinoid.
    MEP-FUBICA
  • HY-W714389
    Cannabifuran
    Cannabifuran is structurally similar to known phytocannabinoids.
    Cannabifuran
  • HY-W748362
    1-(1-Methyl-1H-indol-3-yl)-2-(1-naphthalenyl)ethanone
    1-(1-Methyl-1H-indol-3-yl)-2-(1-naphthalenyl)ethanone is structurally similar to known synthetic cannabinoids.
    1-(1-Methyl-1H-indol-3-yl)-2-(1-naphthalenyl)ethanone
  • HY-12104
    PF-514273
    		Antagonist
    PF-514273 is an orally active, selective antagonist for cannabinoid-1 receptor (CB1) with IC50 of 1 nM. PF-514273 reduces the food uptake in mice, and can be used for obesity research.
    PF-514273
  • HY-172069
    ADB-BICA
    ADB-BICA is structurally classified as a synthetic cannabinoid.
    ADB-BICA
  • HY-W754600
    BZO-CHMOXIZID
    		Activator
    BZO-CHMOXIZID is a Cannabinoid-like analog.
    BZO-CHMOXIZID
  • HY-126550
    Azidoindolene 1
    Azidoindolene 1 is structurally similar to cannabinoid.
    Azidoindolene 1
  • HY-134224
    Arachidonoyl 2'-fluoroethylamide
    Arachidonoyl 2'-fluoroethylamide is an anandamide analog. Arachidonoyl 2'-fluoroethylamide has the potential for the research of intraocular hypertension.
    Arachidonoyl 2'-fluoroethylamide
  • HY-170040
    (±)-6',7'-Epoxy cannabichromene
    (±)-6',7'-Epoxy cannabichromene is a phytocannabinoid metabolite.
    (±)-6',7'-Epoxy cannabichromene
  • HY-114553
    5-Fluoro PB-22 3-carboxyindole metabolite
    5-Fluoro PB-22 3-carboxyindole metabolite (5F-PB-22 3-carboxyindole metabolite) is a metabolite of 5-fluoro PB-22. 5-Fluoro PB-22 is a synthetic cannabinoid.
    5-Fluoro PB-22 3-carboxyindole metabolite
Cat. No. Product Name / Synonyms Application Reactivity
Cannabinoid Receptor Isoform Comparison

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