2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Cannabinoid Receptor

Cannabinoid Receptor

Cannabinoid Receptor

Cannabinoid Receptor

Related Products

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Cannabinoid receptors are currently classified into three groups: central (CB1), peripheral (CB2) and GPR55, all of which are G-protein-coupled. CB1 receptors are primarily located at central and peripheral nerve terminals. CB2 receptors are predominantly expressed in non-neuronal tissues, particularly immune cells, where they modulate cytokine release and cell migration. Recent reports have suggested that CB2 receptors may also be expressed in the CNS. GPR55 receptors are non-CB1/CB2 receptors that exhibit affinity for endogenous, plant and synthetic cannabinoids. Endogenous ligands for cannabinoid receptors have been discovered, including anandamide and 2-arachidonylglycerol.

Cannabinoid Receptor Isoform Specific Products:

Cannabinoid Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W748362
    1-(1-Methyl-1H-indol-3-yl)-2-(1-naphthalenyl)ethanone
    1-(1-Methyl-1H-indol-3-yl)-2-(1-naphthalenyl)ethanone is structurally similar to known synthetic cannabinoids.
    1-(1-Methyl-1H-indol-3-yl)-2-(1-naphthalenyl)ethanone
  • HY-12104
    PF-514273
    		Antagonist
    PF-514273 is an orally active, selective antagonist for cannabinoid-1 receptor (CB1) with IC50 of 1 nM. PF-514273 reduces the food uptake in mice, and can be used for obesity research.
    PF-514273
  • HY-172069
    ADB-BICA
    ADB-BICA is structurally classified as a synthetic cannabinoid.
    ADB-BICA
  • HY-W754600
    BZO-CHMOXIZID
    		Activator
    BZO-CHMOXIZID is a Cannabinoid-like analog.
    BZO-CHMOXIZID
  • HY-126550
    Azidoindolene 1
    Azidoindolene 1 is structurally similar to cannabinoid.
    Azidoindolene 1
  • HY-134224
    Arachidonoyl 2'-fluoroethylamide
    Arachidonoyl 2'-fluoroethylamide is an anandamide analog. Arachidonoyl 2'-fluoroethylamide has the potential for the research of intraocular hypertension.
    Arachidonoyl 2'-fluoroethylamide
  • HY-170040
    (±)-6',7'-Epoxy cannabichromene
    (±)-6',7'-Epoxy cannabichromene is a phytocannabinoid metabolite.
    (±)-6',7'-Epoxy cannabichromene
  • HY-114553
    5-Fluoro PB-22 3-carboxyindole metabolite
    5-Fluoro PB-22 3-carboxyindole metabolite (5F-PB-22 3-carboxyindole metabolite) is a metabolite of 5-fluoro PB-22. 5-Fluoro PB-22 is a synthetic cannabinoid.
    5-Fluoro PB-22 3-carboxyindole metabolite
  • HY-15451R
    MDA 19 (Standard)
    		Agonist
    MDA 19 (Standard) is the analytical standard of MDA 19. This product is intended for research and analytical applications. MDA 19 is a potent and selective agonist of human cannabinoid receptor 2 (CB2), with a Ki of 43.3 nM. MDA 19 has antiallodynic effects in a rat model of neuropathic pain and does not affect rat locomotor activity.
    MDA 19 (Standard)
  • HY-118790
    BB-223-carboxyindole metabolite
    BB-223-carboxyindole metabolite (B-223-Carboxyindolemetabolite) is a metabolite of BB-22. BB-22 is an analog of cannabinoid.
    BB-223-carboxyindole metabolite
  • HY-12761R
    A-836339 (Standard)
    		Agonist
    A-836339 (Standard) is the analytical standard of A-836339. This product is intended for research and analytical applications.
    A-836339 (Standard)
  • HY-168750
    MDMB-FUBICA
    		Agonist
    MDMB-FUBICA, a synthetic cannabinoid, is a potent agonist of the cannabinoid receptors with psychoactive properties. MDMB-FUBICA can be used in electronic cigarette.
    MDMB-FUBICA
  • HY-W768607
    5-Fluoro PB-22 8-hydroxyisoquinoline isomer
    5-Fluoro PB-22 8-hydroxyisoquinoline isomer is structurally similar to known synthetic cannabinoids.
    5-Fluoro PB-22 8-hydroxyisoquinoline isomer
  • HY-150345
    Δ8-THC Glucuronide
    Δ8-THC Glucuronide is a phytocannabinoid metabolite.
    Δ8-THC Glucuronide
  • HY-121600
    GAT229
    		Modulator
    GAT229 is a CB1 positive allosteric modulator (PAM) that effectively reduces intraocular pressure (IOP) in high IOP mouse models and enhances CB1 receptor-mediated IOP-lowering effects. A 0.2% GAT229 solution or 10 mg/kg of GAT229 alone significantly reduces IOP. GAT229 is promising for research related to glaucoma and elevated intraocular pressure.
    GAT229
  • HY-170709
    6',7'-Epoxy cannabigerol
    6',7'-Epoxy cannabigerol is a phytocannabinoid metabolite.
    6',7'-Epoxy cannabigerol
  • HY-110189R
    Pregnenolone monosulfate sodium (Standard)
    		Inhibitor
    Pregnenolone monosulfate (sodium) (Standard) is the analytical standard of Pregnenolone monosulfate (sodium). This product is intended for research and analytical applications. Pregnenolone monosulfate sodium (3β-Hydroxy-5-pregnen-20-one monosulfate sodium) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone monosulfate sodium can protect the brain from cannabis intoxication. Pregnenolone monosulfate sodium is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels.
    Pregnenolone monosulfate sodium (Standard)
  • HY-170047
    11-Nor-9(R)-carboxy-hexahydrocannabinol
    11-Nor-9(S)-carboxy-hexahydrocannabinol (11-Nor-9β-carboxy-HHC) is structurally similar to known phytocannabinoids.
    11-Nor-9(R)-carboxy-hexahydrocannabinol
  • HY-170705
    Δ9-THCP acetate
    Δ9-THCP acetate (Δ9-Tetrahydrocannabiphorol acetate) is structurally similar to known phytocannabinoids.
    Δ9-THCP acetate
  • HY-W775262
    Δ9-Tetrahydrocannabinolic acid
    		Activator
    Δ9-Tetrahydrocannabinolic acid (Δ9-THCA) is a phytocannabinoid that can be heated by cigarette carriers to produce Δ9-THC, thus having psychoactive properties.
    Δ9-Tetrahydrocannabinolic acid
Cat. No. Product Name / Synonyms Application Reactivity
Cannabinoid Receptor Isoform Comparison

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