2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Cannabinoid Receptor

Cannabinoid Receptor

Cannabinoid Receptor

Cannabinoid Receptor

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Cannabinoid receptors are currently classified into three groups: central (CB1), peripheral (CB2) and GPR55, all of which are G-protein-coupled. CB1 receptors are primarily located at central and peripheral nerve terminals. CB2 receptors are predominantly expressed in non-neuronal tissues, particularly immune cells, where they modulate cytokine release and cell migration. Recent reports have suggested that CB2 receptors may also be expressed in the CNS. GPR55 receptors are non-CB1/CB2 receptors that exhibit affinity for endogenous, plant and synthetic cannabinoids. Endogenous ligands for cannabinoid receptors have been discovered, including anandamide and 2-arachidonylglycerol.

Cannabinoid Receptor Isoform Specific Products:

Cannabinoid Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-170705
    Δ9-THCP acetate
    Δ9-THCP acetate (Δ9-Tetrahydrocannabiphorol acetate) is structurally similar to known phytocannabinoids.
    Δ9-THCP acetate
  • HY-172037
    5-Fluoro PB-22 7-hydroxyquinoline isomer
    5-Fluoro PB-22 7-hydroxyquinoline isomer is a synthetic cannabinoid.
    5-Fluoro PB-22 7-hydroxyquinoline isomer
  • HY-W716866
    10α-Hydroxy-exo-THC
    		Ligand
    10α-hydroxy-exo-THC is a cannabinoid compound, a metabolite of Δ9-THC, and can be found in cannabis. 10α-hydroxy-exo-THC can serve as an analytical reference standard for cannabinoid compounds .
    10α-Hydroxy-exo-THC
  • HY-14137S
    Rimonabant-d10 hydrochloride
    		Antagonist
    Rimonabant-d10 (hydrochloride) is the deuterium labeled Rimonabant hydrochloride. Rimonabant hydrochloride (SR 141716A hydrochloride) is a highly potent and selective central cannabinoid receptor (CB1) antagonist with an Ki of 1.8 nM. Rimonabant hHydrochloride (SR 141716A Hydrochloride) also inhibits Mycobacterial membrane protein Large 3 (MMPL3)[1][2].
    Rimonabant-d<sub>10</sub> hydrochloride
  • HY-150347
    Cannabigerol diacetate
    Cannabigerol diacetate is structurally similar to known phytocannabinoids.
    Cannabigerol diacetate
  • HY-170746
    Cannabigerobutolic acid
    Cannabigerobutolic acid (CBGBA) is structurally similar to known phytocannabinoids.
    Cannabigerobutolic acid
  • HY-138121
    PSB-KD107
    		Agonist
    PSB-KD107 is an agonist of the cannabinoid activated orphan G-protein-coupled receptor GPR18, and PSB-KD107 has anti-inflammatory activity. PSB-KD107 can be used in the study of Duchenne muscular dystrophy.
    PSB-KD107
  • HY-W756790
    MDMB-FUBINACA metabolite M1
    MDMB-FUBINACA metabolite M1 is structurally classified as a synthetic cannabinoid.
    MDMB-FUBINACA metabolite M1
  • HY-169041
    Δ4(8)-iso-THC
    Δ4(8)-iso-THC (Δ4(8)-Isotetrahydrocannabinol) is structurally similar to known phytocannabinoids.
    Δ4(8)-iso-THC
  • HY-W109442
    5Br-INACA
    		Control
    5Br-INACA is a precursor in the synthesis of synthetic cannabinoids.
    5Br-INACA
  • HY-168791
    8(R)-Hydroxy-9(S)-Hexahydrocannabinol
    8(R)-Hydroxy-9(S)-Hexahydrocannabinol is a metabolite of hexahydrocannabinol (HHC).
    8(R)-Hydroxy-9(S)-Hexahydrocannabinol
  • HY-169468
    Δ8-THC-C8
    		Activator
    Δ8-THC-C8 is a semi-synthetic cannabinoid. Δ8-THC-C8 is a cannabinoid receptor 1 (CB1) activator with an EC50 of 13.8 nM.
    Δ8-THC-C8
  • HY-139363
    AB-FUBINACA isomer 2
    AB-FUBINACA isomer 2 is a regioisomer of AB-FUBINACA. AB-FUBINACA is an adamantylindole-based synthetic cannabinoid (CB).
    AB-FUBINACA isomer 2
  • HY-113421S
    Linoleoyl ethanolamide-d4
    Linoleoyl ethanolamide-d4 is a deuterated labeled Linoleoyl ethanolamide. Linoleoyl ethanolamide (Linoleic acid monoethanolamide) is classified as a fatty acid ethanolamide. Linoleoyl ethanolamide only weakly binds G-protein-coupled cannabinoid receptors of type-1（CB1）and CB2 receptors, and inhibits the binding of [3H]CP-55,940 with Kis of 10 and 25 μM, respectively. Linoleoyl ethanolamide is 4-fold less potent than anandamide at causing catalepsy in mice and it does not prolong sleep time.
    Linoleoyl ethanolamide-d<sub>4</sub>
  • HY-150335
    Dehydrocannabifuran
    Dehydrocannabifuran (6-Methyl-9-isopropenyl-3-pentyldibenzofuran-1-ol) is a phytocannabinoid derivative.
    Dehydrocannabifuran
  • HY-168794
    11-Hydroxy-9(R)-hexahydrocannabinol
    11-Hydroxy-9(R)-hexahydrocannabinol is a phytocannabinoid metabolite.
    11-Hydroxy-9(R)-hexahydrocannabinol
  • HY-170702
    10α-Hydroxy-Δ8-THC
    10α-Hydroxy-Δ8-THC (10α-Hydroxy-Δ8-tetrahydrocannabinol) is a phytocannabinoid.
    10α-Hydroxy-Δ8-THC
  • HY-168795
    11-Hydroxy-9(S)-hexahydrocannabinol
    11-Hydroxy-9(S)-hexahydrocannabinol is a phytocannabinoid metabolite.
    11-Hydroxy-9(S)-hexahydrocannabinol
  • HY-108067
    SAD448
    		Agonist
    SAD448 is a CB1 and CB2 receptor agonist. SAD448 can lower intraocular pressure (IOP).
    SAD448
  • HY-W775346
    Delta8-THC acetate
    		Modulator
    Delta8-THC acetate (Delta8-tetrahydrocannabinol) is a psychoactive phytocannabinoid, that binds to cannabinoid receptor 1 (CB1 receptor), and exhibits anti-nausea, appetite-stimulating, and anti-inflammatory activities. Delta8-THC acetate exhibits probably neuroprotective efficacy and can be used in anti-anxiety and antidepressant research.
    Delta8-THC acetate
Cat. No. Product Name / Synonyms Application Reactivity
Cannabinoid Receptor Isoform Comparison

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